Quick Answer
Notre Dame, USC, and Ohio State lead all colleges in total NFL Draft picks. Notre Dame has the most with over 520 picks all-time.
Which College Has the Most NFL Draft Picks?
The colleges with the most NFL Draft picks all-time are:
Top 10 Colleges by Total Draft Picks
- Notre Dame – 520+ picks
- USC – 510+ picks
- Ohio State – 480+ picks
- Michigan – 410+ picks
- Penn State – 380+ picks
- Alabama – 370+ picks (and rising fast)
- Oklahoma – 360+ picks
- Tennessee – 350+ picks
- Texas – 350+ picks
- Nebraska – 340+ picks
Notre Dame holds the all-time record, though USC and Ohio State are close behind. Alabama has been dominating recent drafts and is climbing the all-time ranks rapidly.