Southern Illinois NFL Draft Picks
12 total picks | 2 first-rounders | Highest: Lionel Antoine (#3, 1972)
All NFL Draft Picks from Southern Illinois
| Year | Rd | Pick | Team | Player | Pos | College |
|---|---|---|---|---|---|---|
| 2020 | 2 | 64 |  CAR |
 Jeremy Chinn |
SAF | Southern Illinois |
| 2015 | 5 | 143 |  MIN |
 MyCole Pruitt |
TE | Southern Illinois |
| 2015 | — | — |  NA |
Malcolm Agnew | RB | Southern Illinois |
| 2011 | 7 | 207 |  CIN |
 Korey Lindsey |
DB | Southern Illinois |
| 1987 | 4 | 97 |  ATL |
 Ralph Van Dyke |
OT | Southern Illinois |
| 1986 | 4 | 87 |  KC |
 Tom Baugh |
C | Southern Illinois |
| 1984 | 1 | 22 |  SEA |
 Terry Taylor |
CB | Southern Illinois |
| 1983 | 4 | 102 | ATL |
 John Harper |
LB | Southern Illinois |
| 1980 | 2 | 49 |  TB |
 Kevin House |
WR | Southern Illinois |
| 1977 | 6 | 167 | KC |
Andre Herrera | RB | Southern Illinois |
| 1972 | 1 | 3 |  CHI |
Lionel Antoine | OT | Southern Illinois |
| 1969 | 4 | 102 |  NO |
Bob Hudspeth | OT | Southern Illinois |