Isaac Guerendo

San Francisco 49ers 129th pick

RB · Louisville, Wisconsin · 2024–2024

Games

420

Rush Yards

Rush TD

Receptions

152

Rec Yards

Solo Tackles

Draft Details

Year

2024

Round

Round 4

Pick

129th overall

Team

San Francisco 49ers

Position

College

Louisville, Wisconsin

Isaac Guerendo Career Stats

Best statistical season: 2024 with SF (420 rushing yards).

Rushing

Season	Team	G	Car	Rush Yds	Rush TD
2024	SF	16	84	420	4
2025	SF	7	0	0	0
Career		23	84	420	4

Receiving

Season	Team	G	Tgt	Rec	Rec Yds
2024	SF	16	16	15	152
2025	SF	7	0	0	0
Career		23	16	15	152

Returns

Season	Team	G	KR	KR Yds
2024	SF	16	6	163
2025	SF	7	5	100
Career		23	11	263

G = games with at least one recorded statistic; the career games total in the summary above includes every game played.

Source: nflverse · Updated Sep 28, 2026

Isaac Guerendo is a former running back out of Louisville; Wisconsin, selected by the San Francisco 49ers with the 129th overall pick (round 4) in the 2024 NFL Draft. He played 30 regular-season games from 2024 to 2025, with the San Francisco 49ers.

Season Statistics

Season	Team	G	ATT	YDS	TD	Y/A	1D	FUM
2024	SF	13	84	420	4	5.0	18	0
2024	SF	13	84	420	4	5.0	18	0
Career		13	84	420	4	5.0	18	0
Career		0	0	0	0	—	0	0
Career		30	—	420	4	—	—	—

Season	Team	G	TGT	REC	YDS	Y/R	1D
2024	SF	13	16	15	152	10.1	7
2024	SF	13	16	15	152	10.1	7
Career		13	16	15	152	10.1	7
Career		0	0	0	0	—	0
Career		30	—	15	152	10.1	—

NFL Combine Results

Height

6-0

Weight

221 lbs

40-Yard Dash

4.33s

Vertical Jump

41.5"

Broad Jump

129"

3-Cone Drill

6.94s

Shuttle

4.15s

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